A 39-Amino-Acid C-Terminal Truncation of GDV1 Disrupts Sexual Commitment in Plasmodium falciparum-Reference-Cited by-同舟云学术

A 39-Amino-Acid C-Terminal Truncation of GDV1 Disrupts Sexual Commitment in Plasmodium falciparum

Published:2021-05-19 Issue: Volume: Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Tibúrcio Marta¹,Hitz Eva²³,Niederwieser Igor²³,Kelly Gavin⁴,Davies Heledd¹,Doerig Christian⁵,Billker Oliver⁶⁷,Voss Till S.²³^ORCID,Treeck Moritz¹^ORCID

Affiliation:

1. Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom

2. Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland

3. University of Basel, Basel, Switzerland

4. Bioinformatics Science Technology Platform, The Francis Crick Institute, London, United Kingdom

5. Centre for Chronic Infectious and Inflammation Disease, Biomedical Sciences Cluster, School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia

6. Billker Group, Rodent Models of Malaria, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom

7. Department of Molecular Biology and Molecular Infection Medicine Sweden, Umeå, Sweden

Abstract

Transmission of malaria-causing Plasmodium species by mosquitos requires the parasite to change from a continuously growing asexual parasite form growing in the blood to a sexually differentiated form, the gametocyte. Only a small subset of asexual parasites differentiates into gametocytes that are taken up by the mosquito.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.01093-20

Reference43 articles.

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5. The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

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1. Regulation of sexual commitment in malaria parasites — a complex affair;Current Opinion in Microbiology;2024-06

2. Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but may not be linked to sexual commitment;mBio;2024-05-08

3. Expression of the MSPDBL2 antigen in a discrete subset ofPlasmodium falciparumschizonts is regulated by GDV1 but not linked to sexual commitment;2023-11-21

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