Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow

Author:

De Niz Mariana123,Meibalan Elamaran1ORCID,Mejia Pedro14,Ma Siyuan5,Brancucci Nicolas M. B.13ORCID,Agop-Nersesian Carolina6,Mandt Rebecca1,Ngotho Priscilla3ORCID,Hughes Katie R.3,Waters Andrew P.3,Huttenhower Curtis57ORCID,Mitchell James R.4,Martinelli Roberta8,Frischknecht Friedrich9,Seydel Karl B.1011,Taylor Terrie1011,Milner Danny1512,Heussler Volker T.2ORCID,Marti Matthias13ORCID

Affiliation:

1. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.

2. Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland.

3. Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, G12 8TA Scotland, UK.

4. Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

5. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

6. Department of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA.

7. Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA.

8. Beth Israel Deaconess Medical Centre, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

9. Parasitology Centre for Infectious Diseases, University of Heidelberg Medical School, 69120 Heidelberg, Germany.

10. Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre 3, Malawi.

11. College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA.

12. Department of Pathology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA.

Abstract

In vivo visualization of Plasmodium parasites reveals sublocalization, deformability, and mobility of gametocytes in the bone marrow.

Funder

National Institutes of Health

H2020 European Research Council

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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