Author:
Farfour Eric,Charlotte Frédéric,Settegrana Catherine,Miyara Makoto,Buffet Pierre
Abstract
Abstract
Background
Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear.
Methods
The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria.
Results
A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces.
Discussion and conclusion
These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Parasitology
Cited by
85 articles.
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