Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes-Reference-Cited by-同舟云学术

Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Michel-Todó Lucas¹^ORCID,Bancells Cristina¹,Casas-Vila Núria¹,Rovira-Graells Núria¹,Hernández-Ferrer Carles²³,González Juan R.²³,Cortés Alfred¹⁴^ORCID

Affiliation:

1. ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain

2. ISGlobal, Barcelona, Catalonia, Spain

3. Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

4. ICREA, Barcelona, Catalonia, Spain

Abstract

The survival of malaria parasites in the changing human blood environment largely depends on their ability to alter gene expression by epigenetic mechanisms. The active state of Plasmodium falciparum clonally variant genes (CVGs) is associated with euchromatin characterized by the histone mark H3K9ac, whereas the silenced state is characterized by H3K9me3-based heterochromatin.

Funder

MEC | Agencia Estatal de Investigación

"la Caixa" Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03049-22

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