Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle

Author:

Le Roch Karine G.12345,Zhou Yingyao12345,Blair Peter L.12345,Grainger Muni12345,Moch J. Kathleen12345,Haynes J. David12345,De la Vega Patricia12345,Holder Anthony A.12345,Batalov Serge12345,Carucci Daniel J.12345,Winzeler Elizabeth A.12345

Affiliation:

1. Department of Cell Biology ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.

3. Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910–7500, USA.

4. Division of Parasitology, National Institute for Medical Research, London NW7 1AA, UK.

5. Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Abstract

The completion of the genome sequence for Plasmodium falciparum , the species responsible for most malaria human deaths, has the potential to reveal hundreds of new drug targets and proteins involved in pathogenesis. However, only ∼35% of the genes code for proteins with an identifiable function. The absence of routine genetic tools for studying Plasmodium parasites suggests that this number is unlikely to change quickly if conventional serial methods are used to characterize encoded proteins. Here, we use a high-density oligonucleotide array to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle. Genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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