Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrow

Author:

Aguilar Ruth123,Magallon-Tejada Ariel1,Achtman Ariel H.45,Moraleda Cinta13,Joice Regina6,Cisteró Pau1,Li Wai Suen Connie S. N.45,Nhabomba Augusto3,Macete Eusebio3,Mueller Ivo1457,Marti Matthias6,Alonso Pedro L.13,Menéndez Clara123,Schofield Louis45,Mayor Alfredo123

Affiliation:

1. Barcelona Centre for International Health Research (CRESIB), Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain;

2. Centros de Investigación Biomédica en Red de Epidemiología y Salud Pública, Madrid, Spain;

3. Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique;

4. Division of Infection and Immunity, The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia;

5. Department of Medical Biology, The University of Melbourne, Melbourne, Australia;

6. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA; and

7. Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

Abstract

Key Points In P falciparum–infected anemic children, immature gametocytes are more prevalent and abundant in bone marrow than in peripheral blood. P falciparum–infected anemic children are gametocyte carriers that can potentially contribute to malaria transmission.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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