2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site-Reference-Cited by-同舟云学术

2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site

Published:2020 Issue:59 Volume:56 Page:8297-8300
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bozdag Murat¹²³⁴⁵^ORCID,Supuran Claudiu T.¹²³⁴⁵^ORCID,Esposito Davide⁶⁷⁸^ORCID,Angeli Andrea¹²³⁴⁵^ORCID,Carta Fabrizio¹²³⁴⁵^ORCID,Monti Simona Maria⁶⁷⁸^ORCID,De Simone Giuseppina⁶⁷⁸^ORCID,Alterio Vincenzo⁶⁷⁸^ORCID

Affiliation:

1. Neurofarba Department

2. Section of Pharmaceutical and Nutriceutical Sciences

3. Università degli Studi di Firenze

4. Sesto Fiorentino

5. Florence

6. Istituto di Biostrutture e Bioimmagini-CNR

7. Naples

8. Italy

Abstract

2-Mercaptobenzoxazole represents an interesting lead compound alternative to the classical sulfonamides for the development of selective carbonic anhydrase inhibitors.

Funder

Regione Campania

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC02857F

Reference41 articles.

1. Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

2. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

3. Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

4. Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding

5. Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

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