Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases-Reference-Cited by-同舟云学术

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

Published:2012-12-27 Issue:1 Volume:56 Page:293-300
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tars Kaspars¹,Vullo Daniela²,Kazaks Andris¹,Leitans Janis¹,Lends Alons³,Grandane Aiga³,Zalubovskis Raivis³,Scozzafava Andrea²,Supuran Claudiu T.²⁴

Affiliation:

1. Biomedical Research and Study Center, Ratsupites 1, LV 1067, Riga, Latvia

2. Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy

3. Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia

4. Università degli Studi di Firenze, Dipartimento di Scienze Farmaceutiche, Via Ugo Schiff 6, I-50019 Sesto Fiorentino (Firenze), Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301625s

Reference49 articles.

1. Direct Screening of Natural Product Extracts Using Mass Spectrometry

2. Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors

3. Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

4. Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II

5. 7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

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