Affiliation:
1. School of Chemistry and Environmental Engineering Wuhan Institute of Technology Wuhan China
2. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang China
3. Key Laboratory of Green Chemical Process, Ministry of Education Wuhan Institute of Technology Wuhan China
Abstract
AbstractAn efficient synthesis of 2‐substituted thiobenzoazoles in pot manner was reported. Thus, tetramethylthiuram disulfide (TMTD) reacted with 2‐aminothiophenol, 2‐aminophenol, or 1,2‐phenylenediamine to form 2‐mercaptobenzo heterocycles through cyclization, and the subsequent C‐S bonding with 2‐bromoacetophenones gave the desired 2‐substituted thiobenzoazoles containing α‐sulfenylated aromatic ketones smoothly. The method features transition metal‐free, simple operation, mild conditions, short reaction time, and good yields, showing potential synthetic value for the synthesis of a variety of biological or pharmaceutically active compounds.
Funder
State Key Laboratory of Environmental Chemistry and Ecotoxicology
Natural Science Foundation of Henan Province