A captured room temperature stable Wheland intermediate as a key structure for the orthogonal decoration of 4-amino-pyrido[2,3-d]pyrimidin-7(8H)-ones-Reference-Cited by-同舟云学术

A captured room temperature stable Wheland intermediate as a key structure for the orthogonal decoration of 4-amino-pyrido[2,3-d]pyrimidin-7(8H)-ones

Published:2020 Issue:48 Volume:18 Page:9810-9815
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Galve Iñaki¹²³⁴⁵,Ondoño Raül¹²³⁴⁵^ORCID,de Rocafiguera Claudi¹²³⁴⁵^ORCID,Puig de la Bellacasa Raimon¹²³⁴⁵^ORCID,Batllori Xavier¹²³⁴⁵,Puigjaner Cristina⁶⁷⁸⁹⁵^ORCID,Font-Bardia Mercè⁶⁷⁸⁹⁵,Vallcorba Oriol¹⁰¹¹¹²¹³⁵^ORCID,Teixidó Jordi¹²³⁴⁵^ORCID,Borrell José I.¹²³⁴⁵^ORCID

Affiliation:

1. Grup de Química Farmacèutica

2. Institut Químic de Sarrià

3. Universitat Ramon Llull

4. E-08017 Barcelona

5. Spain

6. Unitat de Difracció de Raigs X

7. Centres Científics i Tecnològics

8. Universitat de Barcelona

9. 08028 Barcelona

10. ALBA Synchrotron Light Source

11. carrer de la Lum 2-26

12. Cerdanyola del Vallés

13. Barcelona

Abstract

The dihalo substituted compounds 13 (X = Br) and 26 (X = I) are useful intermediates for the orthogonal decoration of pyrido[2,3-d]pyrimidines. 13 is formed by oxidative rearrangement in DMSO of the captured Wheland bromination intermediate 12.

Funder

Ministerio de Ciencia, Innovación y Universidades

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01785J

Reference35 articles.

1. Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

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3. Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

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