Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors-Reference-Cited by-同舟云学术

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Published:1998-09-17 Issue:22 Volume:41 Page:4365-4377
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boschelli Diane H.¹,Wu Zhipei¹,Klutchko Sylvester R.¹,Showalter H. D. Hollis¹,Hamby James M.¹,Lu Gina H.¹,Major Terry C.¹,Dahring Tawny K.¹,Batley Brian¹,Panek Robert L.¹,Keiser Joan¹,Hartl Brian G.¹,Kraker Alan J.¹,Klohs Wayne D.¹,Roberts Bill J.¹,Patmore Sandra¹,Elliott William L.¹,Steinkampf Randy¹,Bradford Laura A.¹,Hallak Hussein¹,Doherty Annette M.¹

Affiliation:

1. Departments of Medicinal Chemistry, Cancer Research, Vascular and Cardiac Diseases, and Pharmacokinetics and Drug Metabolism, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan 48105

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980398y

Reference56 articles.

1. Tyrosine Kinase Inhibition: An Approach to Drug Development

2. Protein tyrosine kinase inhibitors in cancer treatment

3. Receptor tyrosine kinases as targets for inhibition of angiogenesis

4. Angiogenesis in cancer, vascular, rheumatoid and other disease

5. Current concepts in restenosis following balloon angioplasty

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