A MedChem toolbox for cereblon-directed PROTACs-Reference-Cited by-同舟云学术

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A MedChem toolbox for cereblon-directed PROTACs

Published:2019 Issue:6 Volume:10 Page:1037-1041
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Steinebach Christian¹²³⁴⁵^ORCID,Sosič Izidor⁶⁷⁸⁹^ORCID,Lindner Stefanie¹⁰¹¹¹²⁵,Bricelj Aleša⁶⁷⁸⁹,Kohl Franziska¹²³⁴⁵,Ng Yuen Lam Dora¹⁰¹¹¹²⁵,Monschke Marius¹¹³³⁴⁵,Wagner Karl G.¹¹³³⁴⁵,Krönke Jan¹⁰¹¹¹²⁵^ORCID,Gütschow Michael¹²³⁴⁵^ORCID

Affiliation:

1. Pharmaceutical Institute

2. Pharmaceutical Chemistry I

3. University of Bonn

4. 53121 Bonn

5. Germany

6. Faculty of Pharmacy

7. University of Ljubljana

8. 1000 Ljubljana

9. Slovenia

10. Department of Internal Medicine III

11. University Hospital Ulm

12. 89081 Ulm

13. Pharmaceutical Technology

Abstract

A modular chemistry toolbox was developed for cereblon-directed PROTACs.

Funder

Deutsche Forschungsgemeinschaft

Javna Agencija za Raziskovalno Dejavnost RS

Federation of European Biochemical Societies

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00185A

Reference49 articles.

1. Identification of a Primary Target of Thalidomide Teratogenicity

2. Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

3. Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

4. The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

5. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

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5. Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs;Journal of Medicinal Chemistry;2023-10-30

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