Hydrophobic tag-based protein degradation: Development, opportunity and challenge-Reference-Cited by-同舟云学术

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Hydrophobic tag-based protein degradation: Development, opportunity and challenge

Published:2023-11 Issue: Volume:260 Page:115741
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

He Qindi,Zhao Xiaofei,Wu Donglin,Jia Siming,Liu Canlin,Cheng Zitian,Huang Fei,Chen Yadong,Lu Tao,Lu Shuai^ORCID

Funder

National Natural Science Foundation of China

China Pharmaceutical University

Double First Class University Plan

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference180 articles.

1. Induced protein degradation: an emerging drug discovery paradigm;Lai;Nat. Rev. Drug Discov.,2017

2. Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation;Sakamoto;Proc. Natl. Acad. Sci. U.S.A.,2001

3. Targeted intracellular protein degradation induced by a small molecule: en route to chemical proteomics;Schneekloth;Bioorg. Med. Chem. Lett.,2008

4. PROTACs: past, present and future;Li;Chem. Soc. Rev.,2022

5. Targeting androgen receptor degradation with PROTACs from bench to bedside;Jia;Biomed. Pharmacother.,2023

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3. Design, synthesis, and biological evaluation of RSL3-based GPX4 degraders with hydrophobic tags;European Journal of Medicinal Chemistry;2024-11

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