Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS-Reference-Cited by-同舟云学术

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Published:2015-07 Issue:7559 Volume:523 Page:183-188
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Krönke Jan,Fink Emma C.,Hollenbach Paul W.,MacBeth Kyle J.,Hurst Slater N.,Udeshi Namrata D.,Chamberlain Philip P.,Mani D. R.,Man Hon Wah,Gandhi Anita K.,Svinkina Tanya,Schneider Rebekka K.,McConkey Marie,Järås Marcus,Griffiths Elizabeth,Wetzler Meir,Bullinger Lars,Cathers Brian E.,Carr Steven A.,Chopra Rajesh,Ebert Benjamin L.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature14610.pdf

Reference38 articles.

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2. Krönke, J. et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science 343, 301–305 (2014)

3. Lu, G. et al. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science 343, 305–309 (2014)

4. Gandhi, A. K. et al. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN. Br. J. Haematol. 164, 811–821 (2014)

5. List, A. et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N. Engl. J. Med. 355, 1456–1465 (2006)

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