Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN-Reference-Cited by-同舟云学术

Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN

Published:2013-12-13 Issue:6 Volume:164 Page:811-821
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Gandhi Anita K.¹,Kang Jian¹,Havens Courtney G.¹,Conklin Thomas¹,Ning Yuhong²,Wu Lei¹,Ito Takumi³,Ando Hideki³,Waldman Michelle F.¹,Thakurta Anjan¹,Klippel Anke¹,Handa Hiroshi³,Daniel Thomas O.²,Schafer Peter H.¹,Chopra Rajesh¹

Affiliation:

1. Celgene Corporation Summit NJ USA

2. Celgene Corporation San Diego CA USA

3. Tokyo Medical University Tokyo Japan

Funder

Celgene corporation

Publisher

Wiley

Subject

Hematology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.12708

Reference30 articles.

1. Interleukin 2 gene transcription is regulated by Ikaros‐induced changes in histone acetylation in anergic T cells;Bandyopadhyay S.;Blood,2007

2. Differential aiolos expression in human hematopoietic subpopulations

3. Helios Deficiency Has Minimal Impact on T Cell Development and Function

4. Pharmacokinetics of Lenalidomide in Subjects With Various Degrees of Renal Impairment and in Subjects on Hemodialysis

5. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF‐α;Corral L.G.;Journal of Immunology,1999

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