Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake-Reference-Cited by-同舟云学术

Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake

Published:2018-01-16 Issue:4 Volume:93 Page:402-415
ISSN:0026-895X
Container-title:Molecular Pharmacology
language:en
Short-container-title:Mol Pharmacol

Author:

Gorboulev Valentin,Rehman Saba,Albert Christoph M.,Roth Ursula,Meyer Marleen J.,Tzvetkov Mladen V.,Mueller Thomas D.,Koepsell Hermann

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference42 articles.

1. Structure and Mechanism of the Lactose Permease of Escherichia coli

2. Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions

3. Structural Requirements for Drug Inhibition of the Liver Specific Human Organic Cation Transport Protein 1

4. Functional properties of the polyspecific rat organic cation transporter rOCT2;Arndt;Nova Acta Leopoldina NF 78,1998

5. Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1;Arndt;Am J Physiol Renal Physiol,2001

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Several orphan solute carriers functionally identified as organic cation transporters: Substrates specificity compared with known cation transporters;Journal of Biological Chemistry;2024-09

2. Targeted mutagenesis of negatively charged amino acids outlining the substrate translocation path within the human organic cation transporter 3;Biochemical Pharmacology;2024-05

3. Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2;Nature Structural & Molecular Biology;2023-06-08

4. Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2;2023-03-16

5. A blast from the past: To tame time with metformin;Mechanisms of Ageing and Development;2022-12