Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions-Reference-Cited by-同舟云学术

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Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions

Published:2010-06-22 Issue:6 Volume:11 Page:400-411
ISSN:1470-269X
Container-title:The Pharmacogenomics Journal
language:en
Short-container-title:Pharmacogenomics J

Author:

Ahlin G,Chen L,Lazorova L,Chen Y,Ianculescu A G,Davis R L,Giacomini K M,Artursson P

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Genetics,Molecular Medicine

Link

http://www.nature.com/articles/tpj201054.pdf

Reference46 articles.

1. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM . Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol 1997; 51: 913–921.

2. Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell AL, Karlsson J . Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab Dispos 2007; 35: 1333–1340.

3. Bleasby K, Castle JC, Roberts CJ, Cheng C, Bailey WJ, Sina JF et al. Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition. Xenobiotica 2006; 36: 963–988.

4. Ahlin G, Karlsson J, Pedersen JM, Gustavsson L, Larsson R, Matsson P et al. Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem 2008; 51: 5932–5942.

5. Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D et al. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci USA 2003; 100: 5902–5907.

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