Route Selection and Optimization in the Synthesis of Two Imidazopyridine Inhibitors of DGAT-2-Reference-Cited by-同舟云学术

Route Selection and Optimization in the Synthesis of Two Imidazopyridine Inhibitors of DGAT-2

Published:2018-02-14 Issue:3 Volume:22 Page:360-367
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Bader Scott J.¹,Herr Michael¹,Aspnes Gary E.¹,Cabral Shawn¹,Li Qifang¹,Bian Jianwei¹,Coffey Steven B.¹,Dowling Matthew S.¹,Fernando Dilinie P.¹,Jiao Wenhua¹,Lavergne Sophie Y.¹,Kung Daniel W.¹^ORCID

Affiliation:

1. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

Funder

Pfizer

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00005

Reference19 articles.

1. Thematic Review Series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

2. Identification and Validation of a Selective Small Molecule Inhibitor Targeting the Diacylglycerol Acyltransferase 2 Activity

3. Discovery of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors with a 1H-Pyrrolo[2,3-b]pyridine Core

4. Discovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors

5. Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors

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