Development of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 3. A Scalable Synthesis of Methyl 3-((3,3,3-Trifluoropropyl)thio)propanoate via Thiol

Development of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 3. A Scalable Synthesis of Methyl 3-((3,3,3-Trifluoropropyl)thio)propanoate via Thiol–Ene Chemistry

Published:2019-07-01 Issue:10 Volume:23 Page:2142-2147
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Gray Kaitlyn C.¹^ORCID,Heider Patrick²,McGough Patrick¹,Ondari Mark³,Devaraj Jayachandran¹,Yang Qiang¹^ORCID,Frycek George²,Graham Brian²,Neuman Joseph²,Lorsbach Beth A.⁴,Zhang Yu⁴

Affiliation:

1. Product Design and Process R&D, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, United States

2. Engineering and Process Sciences, The Dow Chemical Company, 1710 Building, Midland, Michigan 48674, United States

3. Global Ag Production Support, Corteva Agriscience, 1710 Building, Midland, Michigan 48674, United States

4. Discovery Chemistry, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, United States

Funder

Corteva Agriscience

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00129

Reference25 articles.

1. Pyrazole Chemistry in Crop Protection

2. Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor

3. Development of the Commercial Route for the Manufacture of a 5-Lipoxygenase Inhibitor PF-04191834

4. An Automated Intermittent Flow Approach to Continuous Suzuki Coupling

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