Development of the Commercial Route for the Manufacture of a 5-Lipoxygenase Inhibitor PF-04191834

Author:

Chekal Brian1,Damon David1,LaFrance Danny1,Leeman Kyle1,Mojica Carlos1,Palm Andrew1,St. Pierre Michael1,Sieser Janice1,Sutherland Karen1,Vaidyanathan Rajappa1,Van Alsten John1,Vanderplas Brian1,Wager Carrie1,Weisenburger Gerald1,Withbroe Gregory1,Yu Shu1

Affiliation:

1. Chemical Research and Development, Pfizer Worldwide R&D-Groton Laboratories, 558 Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference41 articles.

1. Alvira, E.; Graneto, M. J.; Grapperhaus, M. L.; Iyanar, K.; Maddux, T. M.; Mahoney, M. W.; Massa, M. A.; Sample, R. K.; Schmidt, M. A.; Seidel, R. E.; Selbo, J. G.; Tollefson, M. B.; Vonder Embse, R. A.; Wagner, G. M.; Woodard, S. S.WO 2009069044 A1, 2009.

2. Graneto, M. J.; Maddux, T. M.; Masferrer, J. L.US 20080125474 A1, 2008.

3. Development an Efficient Route to the 5-Lipoxygenase Inhibitor PF-04191834

4. Optimization of Imidazole 5-Lipoxygenase Inhibitors and Selection and Synthesis of a Development Candidate

5. 5-Lipoxygenase inhibitors: convenient synthesis of 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues

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