Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors-Reference-Cited by-同舟云学术

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors

Published:2015-11-20 Issue:23 Volume:58 Page:9345-9353
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Imbriglio Jason E.¹,Shen Dong-Ming¹,Liang Rui¹,Marby Ken¹,You Ming¹,Youm Hye Won¹,Feng Zhe¹,London Clare¹,Xiong Yusheng¹,Tata Jim¹,Verras Andreas¹,Garcia-Calvo Margarita¹,Song Xuelei¹,Addona George H.¹,McLaren Dave G.¹,He Timothy¹,Murphy Beth¹,Metzger Dan E.¹,Salituro Gino¹,Deckman Diana¹,Chen Qing¹,Jin Xiaoling¹,Stout Steven J.¹,Wang Sheng-Ping¹,Wilsie Larissa¹,Palyha Oksana¹,Han Seongah¹,Hubbard Brian K.¹,Previs Stephen F.¹,Pinto Shirly¹,Taggart Andrew¹

Affiliation:

1. Department of Discovery Chemistry, ‡Chemistry Modeling, and Informatics, §In Vitro Pharmacology, ∥In Vivo Pharmacology, ⊥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, #Basic Pharmaceutical Sciences, and ○Atherosclerosis, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01345

Reference12 articles.

1. Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia

2. Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

3. Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance

4. Knockdown of Acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice

5. Identification of DGAT2 Inhibitors Using Mass Spectrometry

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life;ACS Medicinal Chemistry Letters;2023-10-02

2. Inhibition of Diacylglycerol Acyltransferase 2 Versus Diacylglycerol Acyltransferase 1: Potential Therapeutic Implications of Pharmacology;Clinical Therapeutics;2023-01

3. Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis;Journal of Medicinal Chemistry;2022-11-02

4. Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control;Progress in Lipid Research;2022-11

5. Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2;Analytical Chemistry;2021-04-05