Improvements to Enable the Large Scale Synthesis of 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833)-Reference-Cited by-同舟云学术

Improvements to Enable the Large Scale Synthesis of 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833)

Published:2018-11-27 Issue:12 Volume:22 Page:1835-1845
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wright Stephen W.¹^ORCID,Li Bryan²^ORCID,Peng Zhihui²,Wei Lulin²,McInturff Emma²,Place David²,Damon David B.²,Singer Robert A.²^ORCID

Affiliation:

1. Medicine Design, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States

2. Chemical Research and Development, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00386

Reference50 articles.

1. Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders

2. Advances in the Discovery of Small-Molecule IRAK4 Inhibitors

3. Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015)

4. IRAK-4 Inhibitors for Inflammation

5. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. DBU‐Catalyzed Glutamation of Phenols, Thiophenols, Secondary Amines and Imides;European Journal of Organic Chemistry;2024-05-31

2. Understanding and Controlling the Mizoroki–Heck Reaction of Cyclic Enones;ACS Catalysis;2024-05-10

3. The Development of Aldehyde Catalytic System;Chemistry – An Asian Journal;2023-10-05

4. Asymmetric synthesis of pyroglutamic acids via Ni(II) complex methodology;Chemistry of Heterocyclic Compounds;2023-07

5. Alternative Approach to the Large-Scale Synthesis of the Densely Functionalized Pyrrolidone BMT-415200;Organic Process Research & Development;2023-03-22