Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
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Published:2017-06-14
Issue:13
Volume:60
Page:5521-5542
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ISSN:0022-2623
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Container-title:Journal of Medicinal Chemistry
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language:en
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Short-container-title:J. Med. Chem.
Author:
Lee Katherine L.ORCID, Ambler Catherine M., Anderson David R., Boscoe Brian P., Bree Andrea G., Brodfuehrer Joanne I., Chang Jeanne S., Choi Chulho, Chung Seungwon, Curran Kevin J., Day Jacqueline E., Dehnhardt Christoph M., Dower Ken, Drozda Susan E., Frisbie Richard K., Gavrin Lori K., Goldberg Joel A., Han Seungil, Hegen Martin, Hepworth David, Hope Heidi R., Kamtekar Satwik, Kilty Iain C., Lee Arthur, Lin Lih-Ling, Lovering Frank E.ORCID, Lowe Michael D., Mathias John P., Morgan Heidi M.1, Murphy Elizabeth A., Papaioannou Nikolaos, Patny Akshay, Pierce Betsy S., Rao Vikram R., Saiah Eddine, Samardjiev Ivan J., Samas Brian M., Shen Marina W. H., Shin Julia H., Soutter Holly H., Strohbach Joseph W., Symanowicz Peter T., Thomason Jennifer R., Trzupek John D., Vargas Richard, Vincent Fabien, Yan Jiangli1, Zapf Christoph W., Wright Stephen W.
Affiliation:
1. Worldwide
Medicinal Chemistry, Pfizer Inc., 1070 Science Center Drive, San Diego, California 92121, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Cited by
108 articles.
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