Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015)
Author:
Affiliation:
1. Discovery Chemistry, Merck Sharp and Dohme Corp., Kenilworth, NJ, USA
Publisher
Informa UK Limited
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/13543776.2016.1202926
Reference88 articles.
1. IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease
2. The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells
3. Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice
4. IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase
5. Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-β (TRIF)
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4. Design of Novel IRAK4 Inhibitors Using Molecular Docking, Dynamics Simulation and 3D-QSAR Studies;Molecules;2022-09-24
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