Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders-Reference-Cited by-同舟云学术

Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders

Published:2014-12-05 Issue:1 Volume:58 Page:96-110
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chaudhary Divya¹,Robinson Shaughnessy²,Romero Donna L.¹

Affiliation:

1. Nimbus Discovery, 25 First Street, Suite 404, Cambridge, Massachusetts 02141, United States

2. Schrödinger Inc., 120 West Forty-Fifth Street, New York, New York 10036, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5016044

Reference105 articles.

1. Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: Finding the right balance in response to danger signals

2. The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation

3. IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

4. MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction

5. IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

Cited by 81 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases;Journal of Medicinal Chemistry;2024-08-16

2. Construction of IRAK4 inhibitor activity prediction model based on machine learning;Molecular Diversity;2024-07-06

3. Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases;Journal of Medicinal Chemistry;2024-05-09

4. Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation;Journal of Medicinal Chemistry;2024-05-02

5. A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors;ACS Medicinal Chemistry Letters;2024-04-26