Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry†-Reference-Cited by-同舟云学术

Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry†

Published:2009-04-16 Issue:9 Volume:52 Page:2940-2951
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Deng Yijun¹,Zhou Xilin¹,Kugel Desmoulin Sita¹,Wu Jianmei¹,Cherian Christina¹,Hou Zhanjun¹,Matherly Larry H.¹,Gangjee Aleem¹

Affiliation:

1. Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 110 East Warren Ave, Detroit, Michigan 48201

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8011323

Reference40 articles.

1. Membrane Transport of Folates

2. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy

3. The folate receptor: What does it promise in tissue-targeted therapeutics?

4. The molecular identity and characterization of a Proton-Coupled Folate Transporter—PCFT; biological ramifications and impact on the activity of pemetrexed—12 06 06

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