Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport-Reference-Cited by-同舟云学术

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Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport

Published:2023-11-15 Issue:12 Volume:14 Page:1682-1691
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Kaku Krishna¹^ORCID,Ravindra Manasa P.¹,Tong Nian¹,Choudhary Shruti¹,Li Xinxin¹,Yu Jianming¹,Karim Mohammad¹,Brzezinski Madelyn²,O’Connor Carrie²,Hou Zhanjun³²^ORCID,Matherly Larry H.³²⁴^ORCID,Gangjee Aleem¹^ORCID

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States

2. Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States

3. Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 4100 John R, Detroit, Michigan 48201, United States

4. Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States

Funder

Division of Cancer Prevention, National Cancer Institute

Duquesne University

Eunice and Milton Ring Endowed Chair for Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00326

Reference50 articles.

1. One-Carbon Metabolism in Health and Disease

2. The Antifolates

3. The Major Facilitative Folate Transporters Solute Carrier 19A1 and Solute Carrier 46A1: Biology and Role in Antifolate Chemotherapy of Cancer

4. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy

5. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy

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