The molecular identity and characterization of a Proton-Coupled Folate Transporter—PCFT; biological ramifications and impact on the activity of pemetrexed

The molecular identity and characterization of a Proton-Coupled Folate Transporter—PCFT; biological ramifications and impact on the activity of pemetrexed—12 06 06

Published:2007-03-06 Issue:1 Volume:26 Page:129-139
ISSN:0167-7659
Container-title:Cancer and Metastasis Reviews
language:en
Short-container-title:Cancer Metastasis Rev

Author:

Zhao Rongbao,Goldman I. David

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Link

http://link.springer.com/content/pdf/10.1007/s10555-007-9047-1.pdf

Reference76 articles.

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2. Matherly, L. H., & Goldman, D. I. (2003). Membrane transport of folates. Vitamins and Hormones, 66, 403–456.

3. Zhao, R., Gao, F., Hanscom, M., & Goldman, I. D. (2004). A prominent low-pH methotrexate transport activity in human solid tumor cells: Contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier. Clinical Cancer Research, 10, 718–727.

4. Zhao, R., Hanscom, M., & Goldman, I. D. (2005). The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells. Biochimica et Biophysica Acta, 1715, 57–64.

5. Qiu, A., Jansen, M., Sakaris, A., Min, S. H., Chattopadhyay, S., Tsai, E., et al. (2006). Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell, 127, 917–928.

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