Multitargeted 6-Substituted Thieno[2,3-<i>d</i>]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism-Reference-Cited by-同舟云学术

Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism

Published:2023-04-26 Issue:5 Volume:6 Page:748-770
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Tong Nian¹^ORCID,Wong-Roushar Jennifer²,Wallace-Povirk Adrianne³,Shah Yesha¹^ORCID,Nyman Morgan C.²,Katinas Jade M.²,Schneider Mathew³,O’Connor Carrie³,Bao Xun⁴,Kim Seongho³⁴,Li Jing³⁴,Hou Zhanjun³⁴,Matherly Larry H.³⁵,Dann Charles E.²,Gangjee Aleem¹^ORCID

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States

2. Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States

3. Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States

4. Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States

5. Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States

Funder

National Cancer Institute

Duquesne University

Eunice & Milton H. Ring Charitable Foundation

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.3c00020

Reference58 articles.

1. Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

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3. Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy

4. The Major Facilitative Folate Transporters Solute Carrier 19A1 and Solute Carrier 46A1: Biology and Role in Antifolate Chemotherapy of Cancer

5. The Antifolates

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