Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents
Author:
Affiliation:
1. Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, Tennessee 38163, United States
2. Preclinical R&D, GTx, Inc., Memphis, Tennessee 38163, United States
Funder
NIH Office of the Director
National Center for Research Resources
National Cancer Institute
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm500764v
Reference24 articles.
1. Microtubules as a target for anticancer drugs
2. An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site
3. Combretastatin A-4 Analogues as Antimitotic Antitumor Agents
4. Antineoplastic Agents. 379. Synthesis of Phenstatin Phosphate1a,
5. BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo
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