X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma-Reference-Cited by-同舟云学术

X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma

Published:2023-05-05 Issue:10 Volume:66 Page:6697-6714
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ren Yichang¹,Wang Yuxi²^ORCID,Liu Jin¹³,Liu Ting¹,Yuan Lin¹,Wu Chengyong²,Yang Zichao¹,Chen Jianjun¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China

2. Targeted Tracer Research and development laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Joint Research Institution of Altitude Health, National Clinical Research Center for Geriatrics, Tianfu Jincheng Laboratory, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

3. Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Medical Research Foundation of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00011

Reference48 articles.

1. The Mechanism of Tubulin Assembly into Microtubules: Insights from Structural Studies