Kinase Scaffold Repurposing for Neglected Disease Drug Discovery: Discovery of an Efficacious, Lapatanib-Derived Lead Compound for Trypanosomiasis-Reference-Cited by-同舟云学术

Kinase Scaffold Repurposing for Neglected Disease Drug Discovery: Discovery of an Efficacious, Lapatanib-Derived Lead Compound for Trypanosomiasis

Published:2013-05-03 Issue:10 Volume:56 Page:3820-3832
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Patel Gautam¹,Karver Caitlin E.¹,Behera Ranjan²,Guyett Paul J.²,Sullenberger Catherine²,Edwards Peter¹,Roncal Norma E.³,Mensa-Wilmot Kojo²,Pollastri Michael P.¹

Affiliation:

1. Department of Chemistry and Chemical Biology and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115, United States

2. Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, United States

3. Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400349k

Reference51 articles.

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2. Target repurposing for neglected diseases

3. Cyclic-nucleotide signalling in protozoa

4. Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

5. Pharmacological Validation of Trypanosoma brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness

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