Pharmacological Validation of Trypanosoma brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness-Reference-Cited by-同舟云学术

Pharmacological Validation of Trypanosoma brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness

Published:2011-11-08 Issue:23 Volume:54 Page:8188-8194
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bland Nicholas D.¹,Wang Cuihua²,Tallman Craig²,Gustafson Alden E.¹,Wang Zhouxi²,Ashton Trent D.³,Ochiana Stefan O.²,McAllister Gregory⁴,Cotter Kristina¹,Fang Anna P.¹,Gechijian Lara¹,Garceau Norman⁵,Gangurde Rajiv⁵,Ortenberg Ron⁵,Ondrechen Mary Jo²,Campbell Robert K.¹,Pollastri Michael P.²

Affiliation:

1. Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, 7 MBL Street, Woods Hole, Massachusetts 02543, United States

2. Northeastern University, Department of Chemistry and Chemical Biology, Hurtig 102, 360 Huntington Avenue, Boston, Massachusetts 02115, United States

3. Boston University, Department of Chemistry, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States

4. Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

5. Blue Sky Biotech, 60 Prescott Street, Worcester, Massachusetts 01605-2661, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201148s

Reference32 articles.

1. Control of Neglected Tropical Diseases

2. Chemotherapy of trypanosomiases and leishmaniasis

3. Target repurposing for neglected diseases

4. An update on phosphodiesterase (PDE) inhibitors: Phosphodiesterases and drug selectivity

5. Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

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