Quinazoline and its Derivatives: Privileged Heterocyclic Scaffolds in Antileishmanial Drug Discovery

Author:

Istanbullu Huseyin

Abstract

Leishmaniasis is a parasitic disease caused by protozoa belonging to the genus Leishmania. Over one billion people are living in areas endemic to leishmaniasis and are at risk of infection. Each year, more than one million new cases are reported. Although few drugs are available for the treatment of leishmaniasis, none of them are ideal due to their high resistance and toxicity risk. Many compounds with quinazoline scaffold were synthesized and reported to have promising antiparasitic and antileishmanial activities. This review aims to evaluate the reported antileishmanial activities of quinazoline and its derivatives with a special focus on their structure-activity relationships.

Publisher

IntechOpen

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