Ligand Specific Efficiency (LSE) Index for PET Tracer Optimization-Reference-Cited by-同舟云学术

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Ligand Specific Efficiency (LSE) Index for PET Tracer Optimization

Published:2016-05-19 Issue:13 Volume:11 Page:1415-1427
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Auberson Yves P.¹^ORCID,Briard Emmanuelle¹,Sykes David²,Reilly John³,Healy Mark³

Affiliation:

1. Novartis Institutes for BioMedical Research; Klybeckstrasse 141 4057 Basel Switzerland

2. University of Nottingham; Cell Signalling Department; Nottingham NG7 2RD UK

3. Novartis Institutes for BioMedical Research; 250 Massachusetts Avenue Cambridge MA 02139 USA

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference31 articles.

1. Finding the sweet spot: the role of nature and nurture in medicinal chemistry

2. Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

3. Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

4. Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

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1. Dipeptide-Derived Alkynes as Potent and Selective Irreversible Inhibitors of Cysteine Cathepsins;Journal of Medicinal Chemistry;2023-03-03

2. A practical approach to the optimization of positron emission tomography imaging agents for the central nervous system;Journal of Labelled Compounds and Radiopharmaceuticals;2022-09-29

3. Evaluation of 5 H ‐Thiazolo[3,2‐α]pyrimidin‐5‐ones as Potential GluN2A PET Tracers;ChemMedChem;2020-07-03

4. A Comparative Study of in vitro Assays for Predicting the Nonspecific Binding of PET Imaging Agents in vivo;ChemMedChem;2019-12-13

5. [ 18 F]PRIMATX, a New Positron Emission Tomography Tracer for Imaging of Autotaxin in Lung Tissue and Tumor‐Bearing Mice;ChemMedChem;2019-07-30

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