Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties-Reference-Cited by-同舟云学术

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

Published:2010-03-25 Issue:6 Volume:1 Page:435-449
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Wager Travis T.¹,Hou Xinjun¹,Verhoest Patrick R.¹,Villalobos Anabella¹

Affiliation:

1. Neuroscience Medicinal Chemistry, Pfizer PharmaTherapeutics Research and Development, 558 Eastern Point Road, Groton, Connecticut 06340

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/cn100008c

Reference25 articles.

1. Can the pharmaceutical industry reduce attrition rates?

2. The influence of drug-like concepts on decision-making in medicinal chemistry

3. Ligand efficiency indices for effective drug discovery

4. The influence of lead discovery strategies on the properties of drug candidates

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