Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose

Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data

Published:2023-01 Issue:1 Volume:64 Page:4-15
ISSN:0893-6692
Container-title:Environmental and Molecular Mutagenesis
language:en
Short-container-title:Environ and Mol Mutagen

Author:

Chepelev Nikolai¹,Long Alexandra S.²,Beal Marc³^ORCID,Barton‐Maclaren Tara³,Johnson George⁴^ORCID,Dearfield Kerry L.⁵,Roberts Daniel J.⁶,van Benthem Jan⁷,White Paul¹

Affiliation:

1. Environmental Health Science and Research Bureau Health Canada Ottawa Ontario Canada

2. Department of Pharmacology and Toxicology University of Toronto Toronto Ontario Canada

3. Existing Substances Risk Assessment Bureau Health Canada Ottawa Ontario Canada

4. Swansea University Medical School Swansea University Swansea UK

5. Retired Burke Virginia USA

6. Charles River Laboratories Skokie Illinois USA

7. National Institute for Public Health and the Environment (RIVM) Bilthoven The Netherlands

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.22517

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5. Drug substances presented as sulfonic acid salts: overview of utility, safety and regulation

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