The use of dose-response data in a margin of exposure approach to carcinogenic risk assessment for genotoxic chemicals in food

Author:

Benford Diane J.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Toxicology,Genetics

Reference10 articles.

1. Opinion of the Scientific Committee on a request from EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic. (Request No EFSA-Q-2004–020). Adopted on 18 October 2005;EFSA (European Food Safety Authority);EFSA Journal,2005

2. Risk assessment of substances that are both genotoxic and carcinogenic

3. Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic

4. COC (Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment). (2012) Risk characterisation methods Ref: COC/G 06 – Version 1.0. https://www.gov.uk/government/publications/cancer-risk-characterisation-methods (accessed August 17, 2015).

5. MacGregor J. T. Frötschl R. White P. A. (2015) IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PODs). Mutat. Res.: Genet. Toxicol. Environ. Mutagen., 783, 55–65 [Epub October 13, 2014], doi:10.1016/j.mrgentox.2014.09.011.

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