Letter to “Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data”
Author:
Affiliation:
1. ToxStrategies, Inc Katy Texas USA
2. ToxStrategies, Inc Mission Viejo California USA
Publisher
Wiley
Subject
Health, Toxicology and Mutagenesis,Genetics (clinical),Epidemiology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.22537
Reference13 articles.
1. An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet
2. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data
3. Hexavalent chromium (Contaminants)
4. NTP. (2007)National toxicology program technical report on the toxicity studies of sodium dichromate dihydrate (CAS no. 7789‐12‐0) administered in drinking water to male and femaleF344/N rats and B6C3F1 mice and male BALB/c andam3‐C57BL/6 mice. NTP Toxicity Report Series Number 72 NIH Publication No. 07‐5964.
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1. Derivation of oral cancer slope factors for hexavalent chromium informed by pharmacokinetic models and in vivo genotoxicity data;Regulatory Toxicology and Pharmacology;2023-12
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