Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose-Reference-Cited by-同舟云学术

Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose

Published:2022-12-22 Issue:2 Volume:64 Page:105-122
ISSN:0893-6692
Container-title:Environmental and Molecular Mutagenesis
language:en
Short-container-title:Environ and Mol Mutagen

Author:

Beal Marc A.¹^ORCID,Audebert Marc²,Barton‐Maclaren Tara³,Battaion Hannah⁴,Bemis Jeffrey C.⁵,Cao Xuefei⁶,Chen Connie⁷,Dertinger Stephen D.⁵,Froetschl Roland⁸^ORCID,Guo Xiaoqing⁶^ORCID,Johnson George⁹^ORCID,Hendriks Giel¹⁰,Khoury Laure¹¹,Long Alexandra S.³,Pfuhler Stefan¹²^ORCID,Settivari Raja S.¹³,Wickramasuriya Shamika³,White Paul⁴

Affiliation:

1. Bureau of Chemical Safety, Health Products and Food Branch Health Canada Ottawa Ontario Canada

2. Toxalim UMR1331 Toulouse University, INRAE Toulouse France

3. Existing Substances Risk Assessment Bureau, Healthy Environments and Consumer Safety Branch Health Canada Ottawa Ontario Canada

4. Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch Health Canada Ottawa Ontario Canada

5. Litron Laboratories Rochester New York USA

6. Division of Genetic and Molecular Toxicology, National Center for Toxicological Research U.S. Food and Drug Administration Jefferson Arkansas USA

7. Health and Environmental Sciences Institute Washington District of Columbia USA

8. Genetic and Reproductive Toxicology BfArM Bonn Germany

9. Swansea University Swansea UK

10. Toxys Oegstgeest Netherlands

11. PrediTox Toulouse France

12. Global Product Stewardship Procter & Gamble Cincinnati Ohio USA

13. Mammalian Toxicology Center Corteva Agriscience Newark Delaware USA

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.22521

Reference65 articles.

1. A comparison of classical and 21st century genotoxicity tools: A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics‐based methods ( TGx‐DDI , whole genome clustering and connectivity mapping)

2. Application of Mass Balance Models and the Chemical Activity Concept To Facilitate the Use of in Vitro Toxicity Data for Risk Assessment

3. Etoposide and merbarone are clastogenic and aneugenic in the mouse bone marrow micronucleus test complemented by fluorescence in situ hybridization with the mouseminor satellite DNA probe

4. Implementing in vitro bioactivity data to modernize priority setting of chemical inventories;Beal M.A.;ALTEX,2022

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