Pharmacokinetic Phenotyping to Predict Drug-Drug Interactions: Time to Divorce the Hybrid Concept of Simultaneous Mechanistic-Based and Exposure-Based Assessment-Reference-Cited by-同舟云学术

Pharmacokinetic Phenotyping to Predict Drug-Drug Interactions: Time to Divorce the Hybrid Concept of Simultaneous Mechanistic-Based and Exposure-Based Assessment

Published:2017-07-29 Issue:1 Volume:103 Page:42-42
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Fuhr Uwe¹

Affiliation:

1. Department I of Pharmacology; Clinical Pharmacology Unit, University Hospital Cologne; Germany

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference5 articles.

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2. Predicting transporter-mediated drug interactions: Commentary on: “Pharmacokinetic evaluation of a drug transporter cocktail consisting of digoxin, furosemide, metformin and rosuvastatin” and “Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A;Zhang;Clin. Pharmacol. Ther.,2017

3. U.S. Food and Drug Administration Guidance for Industry: Drug Interaction Studies - Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm064982.htm 2012

4. Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A;Prueksaritanont;Clin. Pharmacol. Ther.,2017

5. Clarithromycin, midazolam, and digoxin: Application of PBPK modeling to gain new insights into drug-drug interactions and co-medication regimens;Moj;AAPS J.,2017

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