Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Author:

Gazzaz Malaz12,Kinzig Martina3,Schaeffeler Elke45,Jübner Martin6,Hsin Chih-hsuan1,Li Xia1,Taubert Max1,Trueck Christina1,Iltgen-Breburda Juliane7,Kraus Daria18,Queckenberg Christian18,Stoffel Marc1,Schwab Matthias4910,Sörgel Fritz311,Fuhr Uwe1

Affiliation:

1. Department I of Pharmacology; University Hospital Cologne; Germany

2. Department of Clinical Pharmacy, College of Pharmacy; Umm Al-Qura University; Makkah Saudi Arabia

3. Institute for Biomedical and Pharmaceutical Research, Nürnberg-Heroldsberg; Germany

4. Dr. Margarete-Fischer-Bosch Institute of Clinical Pharmacology; Stuttgart Germany

5. University of Tuebingen; Tuebingen Germany

6. Institute of Legal Medicine, Faculty of Medicine; University of Cologne; Germany

7. Pharmacy, University Hospital Cologne; Germany

8. Clinical Trials Centre; University Hospital Cologne; Germany

9. Department of Clinical Pharmacology; University Hospital Tuebingen; Germany

10. Department of Pharmacy and Biochemistry; University of Tuebingen; Tuebingen Germany

11. Institute of Pharmacology; Faculty of Medicine, University Duisburg-Essen; Essen Germany

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference46 articles.

1. WHO Global status report on alcohol and health 2014 WHO http://www.who.int/substance_abuse/publications/global_alcohol_report/en/ 2016

2. Pharmacokinetic and pharmacodynamic drug interactions with ethanol (alcohol);Chan;Clin. Pharmacokinet.,2014

3. Alcohol-medical drug interactions;Johnson;Handb. Clin. Neurol.,2014

4. Pharmacokinetic interactions between acute alcohol ingestion and single doses of benzodiazepines, and tricyclic and tetracyclic antidepressants - an update;Tanaka;J. Clin. Pharm. Ther.,1998

5. Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction;Dorian;Eur. J. Clin. Pharmacol.,1983

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