Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance-Reference-Cited by-同舟云学术

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Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance

Published:2006-07 Issue:3 Volume:63 Page:347-355
ISSN:0939-6411
Container-title:European Journal of Pharmaceutics and Biopharmaceutics
language:en
Short-container-title:European Journal of Pharmaceutics and Biopharmaceutics

Author:

Jouin Delphine,Blanchard Nadège,Alexandre Eliane,Delobel Frédéric,David-Pierson Pascale,Lavé Thierry,Jaeck Daniel,Richert Lysiane,Coassolo Philippe

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Medicine,Biotechnology

Reference35 articles.

1. Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes;Blanchard;Eur. J. Pharm. Sci.,2004

2. Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro–in vivo correlations;Lave;Clin. Pharmacokinet.,1999

3. Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor;Ponsoda;J. Hepatol.,2001

4. Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation;LeCluyse;Eur. J. Pharm. Sci.,2001

5. Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes;Luttringer;Biochem. Pharmacol.,2002

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