Liver organ-on-chip models for toxicity studies and risk assessment

Author:

Messelmani Taha1,Morisseau Lisa1,Sakai Yasuyuki23,Legallais Cécile1,Le Goff Anne1ORCID,Leclerc Eric2,Jellali Rachid1ORCID

Affiliation:

1. Université de Technologie de Compiègne, CNRS, Biomechanics and Bioengineering, Centre de Recherche Royallieu CS 60319, 60203 Compiègne Cedex, France

2. CNRS IRL 2820, Laboratory for Integrated Micro Mechatronic Systems, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8505, Japan

3. Department of Chemical Engineering, Faculty of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

Abstract

This review provides an overview of liver organ-on-chip (OoC) technology, including the general concept, different approaches and recent advances. A particular focus is given to the use of liver OoC in toxicity studies and risk assessment.

Funder

Agence Nationale de la Recherche

Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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