Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes
Author:
Publisher
Elsevier BV
Subject
Pharmaceutical Science
Reference51 articles.
1. Temporal gene expression analysis of monolayer cultured rat hepatocytes;Baker;Chem. Res. Toxicol.,2001
2. Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man;Bayliss;Xenobiotica,1999
3. Prolonged maintenance of active cytochrome P-450 in adult rat hepatocytes co-cultured with another liver cell type;Begue;Hepatology,1984
4. Time course of cytochromes P450 decline during rat hepatocyte isolation and culture: effect of L-NAME;Binda;Toxicol. In Vitro,2003
5. Modelling the loss of metabolic capacities of cultured hepatocytes: application to measurement of Michaelis–Menten kinetic parameters in in vitro systems;Bousquet-Melou;Xenobiotica,2002
Cited by 49 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Metabolism Studies In Vitro and In Vivo;Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays;2024
2. Exploring the Boundaries for In Vitro–In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types;Drug Metabolism and Disposition;2023-08-14
3. Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability?;Drug Metabolism and Disposition;2022-01-27
4. Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data;Drug Metabolism Reviews;2021-05-25
5. Comparative Assessment of Extrapolation Methods Based on the Conventional Free Drug Hypothesis and Plasma Protein-Mediated Hepatic Uptake Theory for the Hepatic Clearance Predictions of Two Drugs Extensively Bound to Both the Albumin And Alpha-1-Acid Glycoprotein;Journal of Pharmaceutical Sciences;2021-03
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3