Towards harmonization of test methods for in vitro hepatic clearance studies

Author:

Louisse Jochem,Alewijn Martin,Peijnenburg Ad A.C.M.,Cnubben Nicole H.P.,Heringa Minne B.,Coecke Sandra,Punt Ans

Funder

National Institute for Public Health

Environment

Dutch Ministry of Agriculture, Nature and Food Quality

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference74 articles.

1. A practical and direct comparison of intrinsic metabolic clearance of several non-CYP enzyme substrates in freshly isolated and cryopreserved hepatocytes;Akabane;Drug Metab. Pharmacokinet.,2012

2. Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data;Ashforth;J. Pharmacol. Exp. Ther.,1995

3. Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips;Baudoin;Xenobiotica.,2013

4. Validation of in vitro methods for human cytochrome P450 enzyme induction: outcome of a multi-laboratory study;Bernasconi;Toxicol. in Vitro,2019

5. EURL ECVAM strategy for achieving 3Rs impact in the assessment of toxicokinetics and systemic toxicity;Bessems,2015

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