Exploring naltrexamine derivatives featuring azaindole moiety via nitrogen-walk approach to investigate their in vitro pharmacological profiles at the mu opioid receptor-Reference-Cited by-同舟云学术

Exploring naltrexamine derivatives featuring azaindole moiety via nitrogen-walk approach to investigate their in vitro pharmacological profiles at the mu opioid receptor

Published:2021-06 Issue: Volume:41 Page:127953
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ma Hongguang^ORCID,Wang Huiqun^ORCID,Gillespie James C.,Mendez Rolando E.,Selley Dana E.,Zhang Yan

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization

3. Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators

4. Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists

5. Synthesis and Structure–Affinity Relationships of Selective High-Affinity 5-HT4 Receptor Antagonists: Application to the Design of New Potential Single Photon Emission Computed Tomography Tracers

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Blocking potential metabolic sites on NAT to improve its safety profile while retaining the pharmacological profile;Bioorganic Chemistry;2024-07

2. IUPHAR review: Recent progress in the development of Mu opioid receptor modulators to treat opioid use disorders;Pharmacological Research;2024-01

3. Endogenous opiates and behavior: 2021;Peptides;2023-06