Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators

Author:

Garai Sumanta1,Kulkarni Pushkar M.1,Schaffer Peter C.1,Leo Luciana M.2,Brandt Asher L.3,Zagzoog Ayat3,Black Tallan3,Lin Xiaoyan4,Hurst Dow P.5,Janero David R.6,Abood Mary E.2ORCID,Zimmowitch Anaelle4,Straiker Alex4,Pertwee Roger G.7,Kelly Melanie8,Szczesniak Anna-Maria8,Denovan-Wright Eileen M.8,Mackie Ken4,Hohmann Andrea G.4,Reggio Patricia H.5,Laprairie Robert B.38,Thakur Ganesh A.1ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States

2. Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, United States

3. College of Pharmacy and Nutrition, University of Saskatchewan, 104 Clinic Pl, Saskatoon, SK S7N2Z4, Canada

4. Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405, United States

5. Center for Drug Discovery, University of North Carolina Greensboro, Greensboro, North Carolina 27402, United States

6. Department of Pharmaceutical Sciences, Bouvé College of Health Sciences, Department of Chemistry and Chemical Biology, College of Science, and Health Sciences Entrepreneurs, Northeastern University, Boston, Massachusetts 02115, United States

7. School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, U.K.

8. Department of Pharmacology, Faculty of Medicine, Dalhousie University, 5850 College St, Halifax, NS, B3H4R2, Canada

Funder

Canadian Institutes of Health Research

National Eye Institute

GlaxoSmithKline

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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