Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication-Reference-Cited by-同舟云学术

Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication

Published:2006-03 Issue:6 Volume:16 Page:1712-1715
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Clark Jeremy L.,Mason J. Christian,Hollecker Laurent,Stuyver Lieven J.,Tharnish Phillip M.,McBrayer Tamara R.,Otto Michael J.,Furman Phillip A.,Schinazi Raymond F.,Watanabe Kyoichi A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference10 articles.

1. Current therapy for chronic hepatitis C

2. Inhibition of Hepatitis C Virus RNA Replication by 2′-Modified Nucleoside Analogs

3. Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

4. Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

5. A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

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