Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase-Reference-Cited by-同舟云学术

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

Published:2004-03-26 Issue:9 Volume:47 Page:2283-2295
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Eldrup Anne B.¹,Allerson Charles R.¹,Bennett C. Frank¹,Bera Sanjib¹,Bhat Balkrishen¹,Bhat Neelima¹,Bosserman Michele R.¹,Brooks Jennifer¹,Burlein Christine¹,Carroll Steven S.¹,Cook P. Dan¹,Getty Krista L.¹,MacCoss Malcolm¹,McMasters Daniel R.¹,Olsen David B.¹,Prakash Thazha P.¹,Prhavc Marija¹,Song Quanlai¹,Tomassini Joanne E.¹,Xia Jie¹

Affiliation:

1. Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, California 92008, Department of Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, and Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030424e

Reference32 articles.

1. Hepatitis C Virus NS5B Protein Is a Membrane-Associated Phosphoprotein with a Predominantly Perinuclear Localization

2. Structure and organization of the hepatitis C virus genome isolated from human carriers

3. Evolution, synthesis and SAR of tripeptide α-ketoacid Inhibitors of the hepatitis C virus NS3/NS4A serine protease

4. A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease

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